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Symptoms
Marburg Hemorrhagic Fever
After an incubation period of 5-10 days, the onset of the disease is sudden and is marked by fever, chills, headache, and myalgia. Around the fifth day after the onset of symptoms, a maculopapular rash, most prominent on the trunk (chest, back, stomach), may occur. Nausea, vomiting, chest pain, a sore throat, abdominal pain, and diarrhea then may appear. Symptoms become increasingly severe and may include jaundice, inflammation of the pancreas, severe weight loss, delirium, shock, liver failure, and multi-organ dysfunction.
Like Ebola, Marburg is an enveloped, single-stranded, unsegmented, negative-sense RNA virus. It has the same characteristic filamentous structure, can appear shaped like a U, a 6, or spiraled like a snail; and can sometimes be branched. (Refer to Links, at the bottom of this page, for electron micrographs.) They tend to include long noncoding regions at their 3' and/or 5' ends, which probably contributes to the stability of the viral transcript.
Survival
No. As with exposure to other filoviruses, exposure to Marburg does not confer subsequent immunity. The antibody response in convalescent patients does not neutralize or protect against subsequent infection by Marburg virus.er yourself
Is it treatable?
Treatment
Supportive therapy (there is no specific treatment for Marburg hemorrhagic fever. However, the virus itself is sensitive to lipid solvents, detergents, commercial hypochlorite disinfectants, and phenolic disinfectants. The virus can also be destroyed by ultraviolet and gamma radiation.
